Neeraj Agarwal
Associate Professor
Neeraj Agarwal

Academic Profile:

  • Reader F (January 2011 - ), Centre for Excellence in Basic Sciences, Mumbai, India.
  • Assistant Professor (April 2010-December 2010), Centre for Excellence in Basic Sciences, Mumbai, India.
  • Post-doc: Position from April 2009-Dec 2009, Max Planck Institute for Polymer Research, Mainz, Germany. (MPIP, Mainz)
  • Visiting Fellow: Position from May 2006-March 2009, Department of Chemical Sciences, Tata Institute of Fundamental Research, Colaba, Mumbai. (TIFR)
  • Post-doc. Associate: Oct. 2004-Dec 2005, Bowling Green State University, Bowling Green, Ohio (BGSU, Ohio)
  • Ph.D: 2004 Department of Chemistry, Indian Institute of Technology, Bombay (IIT-Bombay)

Selected Publications:

  • Ferrocene catalysed heteroarylation of BODIPy and reaction mechanism studies by EPR and DFT methods. Swati Dixit, Mahendra Patil and Neeraj Agarwal RSC Advances, 2016, DOI: 10.1039/C6RA03705D.

  • Synthesis, photophysical and electrochemical studies of acridone-amine based donor – acceptors for hole transport materials. Bharat K. Sharma, Azam M. Shaikh, Neeraj Agarwal and Rajesh M. Kamble, RSC Adv, 2016, 6, 17129-17137.

  • Synthesis of highly emissive 1,8-diaryl anthracene derivatives and fabrication of their micro/nanostructures. Neeraj Agarwal, Manish Patil and Mahendra Patil, RSC Adv., 2015, 5, 98447–98455.

  • Effects of 2‑amino‑8‑hydroxyquinoline interaction on the conformation of physiological isomers of human serum albumin. Sonali M. Shiriskar, Neeraj Agarwal, Raghuvir R. S. Pissurlenkar and Basir Ahmad. Eur Biophys J., DOI 0.1007/s00249-015-1014-0

  • Synthesis and photophysical studies of heteroaryl substituted-BODIPy derivatives for biological applications. Dipti Lakhe, Karthika K. Jairaj, Madhura Pradhan, Uma Ladiwala and Neeraj Agarwal Tetrahedron Letters, 2014, 55, 7124-7129.

  • Synthesis and studies of aza-BODIPY based pi-conjugates for organic electronic applications. Tamanna K. Khan, Preeti Sheokand and Neeraj Agarwal Eur. J. Org.Chem. 2013, 7, 1416.

  • Kamtekar N, Pandey A, Agarwal N, Pissurlenkar  RRS, Borana B, Ahmad B* (2013) Interaction of Multimicrobial Synthetic Inhibitor 1,2-Bis(2-Benzimidazolyl)-1,2-Ethanediol with Serum Albumin: Spectroscopic and Computational Studies. PLoS ONE 2013, 8(1) e3872.

  • Synthesis, photophysical, electrochemical and thermal studies on carbazole-based acceptor molecules for heterojunction solar cell. Shibdas Banerzee, Farman Ali, Pabitra K. Nayak, Neeraj Agarwal, Thin Solid Films 2012, 520, 2644.

  • Tuning of HOMO levels of carbazole derivatives: New molecules for blue OLED. Neeraj Agarwal, Pabitra K. Nayak, Farman Ali, Meghan P. Patankar, K. L. Narasimhan, N. Periasamy, Synthetic Metals, 2011, 161, 466-473.

  • The synthesis and characterization of photonic materials composed of substituted fluorene donors and porphyrin acceptor. Neeraj Agarwal, Dyes and Pigments 2009 83, 328.

  • Ultrafast Energy Transfer in Oligofluorene−Aluminum Bis(8-hydroxyquinoline)acetylacetone Coordination Polymers. Victor A. Montes, Grigory V. Zyryanov, E. Danilov, Neeraj Agarwal, Manuel A. Palacios, Pavel Anzenbacher, Jr.J. Am. Chem. Soc. 2009, 131, 1787.

  • Synthesis, characterization, photophysical and electrochemical properties of new phosphorescent dopants for OLEDs. Neeraj Agarwal, Pabitra K. Nayak, Tetrahedron Letters, 2008, 49, 2710.

  • Molecular-Wire Behavior of OLED Materials: Exciton Dynamics in Multichromophoric Alq3-OligoFluorene-Pt(II)Porphyrin Triads. Victor A. Montes, Cesar B. Pérez, Neeraj Agarwal, Joseph Shinar, Pavel Anzenbacher, Jr. J. Am. Chem. Soc. 2006, 128, 12436.

  • Thiaporphyrins with four, two and one meso-free carbons: synthesis and functionalization. Neeraj Agarwal, C-H. Hung, M. Ravikanth, Eur J. Org. Chem. 2003, 3730.

  • Synthesis and crystal structure of 2,3,12,13-tetraalkoxy-21,23-dithiaporphyrins. Neeraj Agarwal, Sarada P. Mishra, A. Kumar, C-H. Hung, M. Ravikanth, Chem Comm. 2002, 2642.

Avinash Kale
Avinash Kale


  • Ph.D. in Protein crystallography, Rijksuniversite it Groningen, Groningen, the Netherlands. (Dec 2002-2007).
  • Masters in Physical chemistry, Indian Institute of Technology, Bombay, India (March 2001).
  • Bachelors in Chemistry Honors, Holkar Science College, Indore, India (March 1998).


  • Visiting Assistant Professor- Centre for Excellence in Basic Sciences, Mumbai, India (May 2016 - )
  • Visiting Scientist-II - Centre for Excellence in Basic Sciences, Mumbai, India (Apr 2013 - Apr 2016)
  • Research Associate (RA-3) -Center for Excellence in Basic Sciences, Mumbai, India (Jan 2013 - Mar 2013)
  • Visiting Scientist -Bhabha Atomic Research Center, Trombay, Mumbai, India. (Nov 2011- Dec 2012)
  • Post-doc Scientist - University of Oulu, Oulu, Finland. (Apr 2011-Sep 2011)
  • Post-doc Research Associate (PDRA) - University of Sheffie ld, Sheffie ld, United Kingdom. (Jan 2008- Dec 2010)
  • Project Assistant - Center for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India. (May 2001-Oct 2002)

Research areas:

  • Actin regulation; Mosquito Borne Diseases; ageing in peroxisomes; searching cure for depression; and structural insights of resolvases.
  • My broad area of research includes Actin regulation, and Mosquito Borne Diseases.

Selected Publications

  • Khavnekar, S.; Dantu, S.C.; Sedelnikova, S.; Ayora, S.; Rafferty, J.; and Kale, A. “Structural insights into dynamics of RecU-HJ complex formation elucidates key role of NTR and stalk region towards formation of reactive state” Nucleic Acid Research (November 2016); DOI: 10.1093/nar/gkw1165.
  • Chavan, R.; Colvin D.; Dahake, R.; Chowdhary, A.; Mukherjee, S.; Kale, A. “Differential proteomic analysis of respiratory samples from patients suffering from influenza” Virus Disease (July 2016); DOI: 10.1007/s13337-016-0332-x.
  • Dantu, S.C.; Khavnekar, S.; Kale, A. “Conformational dynamics of Peb4 exhibit “mother’s arms” chain model: A molecular dynamics study” Journal of biomolecular Structure & Dynamics (July 2016) DOI: 10.1080/07391102.2016.1209131.
  • Mothi, N.; Muthu, S.A.; Kale, A.; Ahmad, B. “Curcumin promotes fibril formation in F isomer of human serum albumin via amorphous aggregation” Biophysical Chemistry (August 2015) DOI: 10.1016/j.bpc.2015.08.002.
  • Kale, A.; Hire, R., Hadapad, A.; D'souza, S.F.; Kumar, V. “Interaction between mosquito-larvicidal LysinibacillusSphaericus Binary toxin components: analysis of complex formation” Insect Biochemistry and Molecular Biology (November 2013) DOI:10.1016/j.ibmb.2013.07.011.
  • Gupta, G.D.; Kale, A.; Kumar, V. “Molecular evolution of translin superfamily proteins with in the genomes of eubacteria, archaea and eukaryotes” Journal of Molecular Evolution (December 2012) DOI:10.1007/s00239-012-9534-z. (Equal contribution; cover page article; cover page designed by me).
  • Kale, A.;Suwarnchat, C.; Phansopa, C.; Craven, J.; Rafferty, J.B.; Kelly, D.J. “The virulencefactor PEB4 and the periplasmic protein Cj1289 are two structurally related SurA-likechaperones in the human pathogen Campylobacter jejuni” Journal of Biological Chemistry (June 2011) DOI: 10.1074/jbc.M111.220442.
  • Kale, A.;Pijning, T.; Sonke, T.; Dijkstra, B.W.; Thunnissen, A.M.W.H. “Crystal Structure of the Leucine Aminopeptidase from Pseudomonas putida Reveals the Molecular Basis for its Enantio-selectivity and Broad Substrate Specificity” Journal of Molecular Biology (May 2010) DOI: 10.1016/j.jmb.2010.03.042.

Chemistry Faculty

Core Faculty

V K Jain

V. K Jain


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Phone:+91-22-2652 4989
+91-22-2653 2143


Prof. Swapan Ghosh

Distinguished Professor and Dean, Academic Affairs

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Neeraj Agarwal

Associate Professor

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Basir Ahmed

UGC Assistant Professor

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Avinash Kale


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Phone:+91-22-2653 2134


Mahendra Patil


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Sinjan Choudhary

Sinjan Choudhary

Assistant Professor

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Phone:+91-22-2653 0225


Veera Mohan Rao

SERB National Post-Doctoral Fellowship


Kavitha Rachineni

SERB National Post-Doctoral Fellowship


R.V. Hosur

Visiting Faculty


Sunita Patel

Visiting Scientist-II


Adjunct Faculty

D.K. Palit

Emeritus Professor

Mahendra Patil
Assistant Professor
Mahendra Patil |


  • M.Sc. (Organic Chemistry) – University of Mumbai (2000)
  • Ph.D. – Indian Institute of Technology, Bombay (2009)


  • Visiting Scientist – I (April 2013 – till present) Centre for Excellence for Basic Sciences, University of Mumbai
  • Research Associate (October 2012 – March 2013 Centre for Excellence for Basic Sciences, University of Mumbai
  • Post-doctoral Research fellow (April 2009 – June 2012) Max-Planck-Institut für Kohlenforschung, Germany

Research Areas:

  • Organic Chemistry and Catalysis

Selected Publications:

  • Kharade A., Patil M., Patil M. ‘Anion Induced Dediazotization of In Situ Generated Aniline Diazonium Compounds in Direct C–H Arylation of Heteroarenes: An Experimental and Computational Study’ ChemistrySelect, 2017, [Accepted for Publication]’
  • Patil, M. ‘Revised Mechanism of the α-Ketoacid Hydroxylamine Amide Forming Ligations’ Org. Biomol. Chem. 2016, [Accepted for Publication] [Impact factor: 3.559]
  • Patil, M. ‘Mechanistic Insights into the Initiation step of the Base Promoted Direct C–H Arylation of Benzene in the Presence of Additive’ J. Org. Chem. 2016, 81, 632–639. [Impact factor: 4.721]
  • Dixit, S.; Patil, M.; Agarwal, N. ‘Ferrocene Catalysed Heteroarylation of BODIPy and Reaction Mechanism Studies by EPR and DFT methods’ RSC Adv., 2016, 6, 47491-47497. [Impact Factor: 3.28]
  • Patil, M. Thiel, W. ‘Mechanism of Ylide Transfer to carbonyl compounds: Density Functional Theory Calculations’ Eur. J. Org. Chem. 2016, 830-839. [Impact factor: 3.065]
  • Heggen, B.; Patil, M.; Thiel, W. ‘Cyclization of an α,β-unsaturated hydrazone catalyzed by a BINOL-phosphoric acid: pericyclic or not?’ J. Comp. Chem. 2016, 37, 280–285. [Impact factor: 3.13]
  • Agarwal, N.; Patil M.; Patil M. ‘Synthesis of Highly Emissive 1,8-diaryl Anthracene Derivatives for Organic Light Emitting Devices: Substituent Effect on Fabrication of Micro/nanostructure’ RSC Adv., 2015, 5, 98447–98455. [Impact Factor: 3.28]
  • Yamajala, K. B. D.; Patil M.; Banerjee, S. ‘Pd-catalyzed regioselective arylation on C-5 position of N-aryl 1,2,3-Triazoles’ J. Org. Chem. 2015, 80, 3003. [Impact factor: 4.721]
  • Götze, J.; Karasulu B.; Patil, M. Thiel W. ‘Vibrational relaxation as the driving force for wavelength conversion in the peridinin-chlorophyll a-protein’ BioChim. Biophys. Acta, 2015, 12, 1509. [Impact factor: 5.323]
  • Kumari, D.; Anjitha S. G.; Pant, C. S.; Patil M.; Singh, H.; Banerjee, S. ‘Synthetic approach to novel azido esters and their utility as energetic plasticizers’ RSC Adv. 2014, 4, 39924. [Impact Factor : 3.84]
  • Karasulu, B.; Patil M.; Thiel W. ‘Amine Oxidation Mediated by Lysine-Specific-Demethylase 1 (LSD1): QM/MM Insights into Mechanism and Role of Lysine 661’ J. Am. Chem. Soc. 2013, 135, 13400-13413. [Impact factor: 10.677]
  • Haung, X.; Patil M.; Farès, C.; Thiel, W.; Maulide, N. ‘Sulfur(IV)-Mediated Transformations; From Ylide Transfer to Metal-Free Arylation of Carbonyl Compounds.’ J. Am. Chem. Soc. 2013, 19, 7312-7323. [Impact factor: 10.677]
  • Patil, M.; Loerbroks, C.; Thiel W. ‘Mechanism of the Pummerer Reaction; A Computational Study. Org. Lett. 2013, 15, 1682-1685. [Impact factor: 6.142]
  • Čorić, I.; Kim, J. H.; Vlaar, T.; Patil, M.; Thiel, W.; List, B. ‘Brønsted Acid Catalyzed Asymmetric SN2-Type O-Alkylations’ Angew. Chem. Int. Ed. 2013, 52, 3490-3493. [Impact factor: 13.455]
  • [6] Carrera, J.; Patil M.; Thiel W.; Alcarazo, M ‘Exploiting the π-Acceptor Properties of Carbene-stabilized Phosphorus Centered Trications [L3P]3+ : Applications in Pt (II) catalysis’ 2012, 134, 16753. [Impact factor : 10.677]
  • Patil, M. Thiel W. ‘Origin of Selectivity of Tsuji-Trost Allylic Alkylation of Lactones: Highly Ordered Transition States with Lithium-Containing Enolates’ Chem. Eur. J. 2012, 18, 10408. [Impact factor: 5.831]
  • Petuškova, J.; Patil M.; Holle, S.; Lehmann, C. W.; Thiel, W.; Alcarazo, M. ‘Synthesis, structure and Reactivity of Carbene-Stabilized Phosphorus(III)-Centered trications [L3P]+3’ J. Am. Chem. Soc. 2011, 133, 20758. [Impact factor : 9.023]
Sinjan Choudhary
Assistant Professor
Sinjan Choudhury


  • PhD (Chemistry), Indian Institute of Technology Bombay, Mumbai (2012)
  • MSc (Biotechnology), Jawaharlal Nehru University, New Delhi (2008)


  • Assistant Professor : UM- DAE Centre for Excellence in Basic Sciences (January 2016 onwards)
  • Research Associate: UM- DAE Centre for Excellence in Basic Sciences (January 2013-December 2015)
  • Research Associate: Department of Chemistry, IIT Bombay (October 2012-December 2012)


  • Inhibition of protein fibrillation/aggregation by natural and synthetic products as potential inhibitors of aggregation-related diseases.
  • Biophysical investigation of biologically important systems: drug-protein and Protein-solvent Interactions.

Selected Publications

  • “Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol” Madhura Pradhan, Suri C, Sinjan Chudhary, Pradeep Kumar Naik, Manu Lopus. J. biomol. Struct. Dyn.(2016) 1-10.
  • “Synergistic Inhibition of Protein Fibrillation by Proline and Sorbitol: Biophysical Investigations” Sinjan Choudhary, Shreyada N Save, Nand Kishore, Ramakrishna V. Hosur. PlosOne (2016) 11(11):e0166487. doi:10.1371/journal.pone.0166487.
  • “Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations” Tejashree Mahaddalkar, Pradeep Kumar Naik, Sinjan Choudhary, Naresh Manchukonda, Srinivas Kantevari, Manu Lopus. J. biomol. Struct. Dyn. (2016) 1-10. doi:
  • “Rational Drug Design and Future Directions: Thermodynamic Perspective” Eva Judy, Sinjan Choudhary, Nand Kishore. Austin Biomol. Open Access. 1 (2016) 1003.
  • “Subtle Alterations in Microtubule Assembly Dynamics by Br-TMB-Noscapine Strongly Suppress Triple-Negative Breast Cancer Cell Viability Without Mitotic Arrest” Tejashree Mahaddalkar, Naresh Manchukonda, Sinjan Choudhary, Sanith Cheriyamundath, Neha Mohanpuria, Srinivas Kantevari, Manu Lopus, Chemistry Select 1 (2016) 4313 – 4319.
  • “Competitive binding of anticancer drugs 5-fluorouracil and cyclophosphamide with serum” Anu A Thoppil, Sinjan Choudhary, Nand Kishore, Biochimica et BiophysicaActa 1860 (2016) 917–929.
  • “Inhibition of insulin fibrillation by osmolytes: Mechanistic Insights”, Sinjan Choudhary, Nand Kishore, Ramakrishna V. Hosur, Scientific Reports (2016) 5:17599 | DOI: 10.1038/srep17599.
  • “Understanding thermodynamics of drug partitioning in micelles and delivery to proteins: Studies with naproxen, diclofenac sodium, tetradecyltrimethylammonium bromide, and bovine serum albumin”Paurnima Talele, Sinjan Choudhary, Nand Kishore, J. Chem.Thermodynamics 92 (2016) 182–190.
  • “Thermodynamic insights into drug-surfactant interactions: study of the interactions of naporxen, diclofenac sodium, neomycin, and lincomycin with hexadecytrimethylammonium-bromide by using isothermal titrationcalorimetry” Sinjan Choudhary, PaurnimaTalele, Nand Kishore, Colloids Surf B Biointerfaces 132 (2015) 313-321.
  • “Ribosomal Protein P2 from apicomplexan parasite, Toxoplasma gondii is intrinsically a molten globule” Pushpa Mishra, Sinjan Choudhary, Ramakrishna V. Hosur, Biophysical Chem. 200-201 (2015) 27-33.
  • “Molten globule nature of Plasmodium falciparum P2 homo-tetramer” Pushpa Mishra, Sinjan Choudhary, Sujoy Mukherjee, DishaSengupta, Shobhona Sharma, R.V. Hosur, Biochemistry and Biophysics Reports1 (2015) 97-107.
  • “Addressing mechanism of fibriliization/aggregation and its prevention in presence of osmolytes: spectroscopic and calorimetric approach. Sinjan Choudhary, Nand Kishore, PLOS ONE (2014) 9(8): e104600. doi:10.1371/journal.pone.0104600.
  • “Drug-protein interactions in micellar media: Thermodynamic aspects”, Sinjan Choudhary, Nand Kishore, J. Coll. Interface Sci. 413 (2014) 118-126.
  • “Effects of Hesperidin, a Flavanone Glycoside Interaction on the Conformation, Stability and Aggregation of Lysozyme: Multispectroscopic and Molecular Dynamic Simulation Studies”, Aditi Ratnaparkhi, Shivani A Mutthu, Sonali M Shiriskar, Raghuvir R S Pissurlenkar, Sinjan Choudhary, Basir Ahmad, J. biomol. Struct. Dyn.33 (2014) 1866-1879.
  • “Binding thermodynamics of the recognition of the antibiotic drug oxytetracycline with bovine serum albumin” NeelamKeswani, Sinjan Choudhary, Nand Kishore,J. Chem. Thermodyn. 58 (2013) 196-205.
  • “Unraveling the energetics and mode of the recognition of antibiotics tetracycline and rolitetracycline by bovine serum albumin”, Sinjan Choudhary, Nand Kishore,Chem. Biol. Drug Des. 80 (2012) 693-705.
  • Physico-chemical insights into the Binding of Diclofenac Sodium and CefotaximeSodium to Serum Albumin : Calorimetry and Spectroscopy”, Ruchika Sharma, Sinjan Choudhary, Nand Kishore, Eur. J. Pharm. Sci. 46 (2012) 435-445.
  • “Interactions of some short peptides with the osmolyte trimethylamine N-oxide inaqueous solution: physico-chemical insights” Sinjan Choudhary, Nand Kishore, J. Chem. Thermodyn. 52 (2012) 36-42.
  • “Thermodynamics of the interactions of a homologous series of some aminoacids with trimethylamine N-oxide: Volumetric, compressibility and calorimetricstudies”, Sinjan Choudhary, Nand Kishore, J. Chem. Thermodyn. 43 (2011)1541-1551.
  • “Interaction of weakly bound antibiotics, neomycin and lincomycin with serumalbumin : Biophysical approach”, NeelamKeswani, Sinjan Choudhary, Nand Kishore, J. Biochem. 148 (2010) 71-84.


UM-DAE Centre for Excellence in Basic Sciences
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About Us

CBS was set up by the Department of Atomic Energy and the University of Mumbai in 2007. CBS offers a 5 year integrated MSc program in Basic Sciences, with undergraduate teaching embedded in a postgraduate and research environment, for students who have completed 10+2 schooling or its equivalent.