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Subhojit Sen
Subhojit Sen
Ramalingaswami Fellow
Subhojit Sen

Education:

  • Ph.D., Molecular Biology, Tata Institute of Fundamental Research, Mumbai, India.  (2001)
  • Master of Science, Microbiology, M.S. University of Baroda, India. (1996)
  • Bachelor of Science, Microbiology, Vivekanand Education Society, Mumbai, India. (1994)

Positions:

  • UGC Ramalingaswami Fellow, DBT funded 5yr programme for independent research (current).
  • Research Fellow, Laboratory of Tumor Biology, Dr. Stephen Baylin, Johns Hopkins Med. Inst., Baltimore, USA (2013)
  • Visiting Fellow, Laboratory of Molecular and Cell Biology, Dr. Carl Wu, National Cancer Institute, NIH, USA (2007)
  • Post Doctoral Fellow, Dr. B.J. Rao, Tata Institute of Fundamental Research (2002)

Research:

  • EPIGENETICS of Behaviour and Diseases

Selected Publications:

  • Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell, May 2011
  • ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science, January 2004
  • Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus. Cancer Research, October 2010
  • Chz1, a nuclear chaperone for histone H2AZ. Molecular Cell, February 2007
  • Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nature Structural and Molecular Biology, December 2005
  • NA dynamics in RecA-DNA filaments: ATP hydrolysis-related flexibility in DNA. Biochemistry, October 2003
  • RecA-promoted sliding of base pairs within DNA repeats: quantitative analysis by a slippage assay. Biochemical Biophysics Res. Comm., August 2002
  • Local repeat sequence organization of an intergenic spacer in the chloroplast genome of Chlamydomonas reinhardtii leads to DNA expansion and sequence scrambling: a complex mode of "copy-choice replication"? Journal of Biosciences, December 2001
  • Real time fluorescence analysis of the RecA filament: implications of base pair fluidity in repeat realignment. FEBS Letters, March 2001
  • RecA realigns sub-optimally paired frames of DNA-repeats through a process that requires ATP hydrolysis. Biochemistry, August 2000
  • ATP-hydrolysis dependent conformational switch modulates the stability of MutS-mismatch complexes. Nucleic Acids Research, February 2000

Details about Laboratory of Epigenetics of Behaviour and Diseases at CBS.

Address

UM-DAE Centre for Excellence in Basic Sciences
Health Centre, University of Mumbai,
Vidyanagari Campus, Kalina, Santacruz (East), Mumbai 400098, India.
Phone: 91-22-26524983
Fax: 91-22-26524982
General Enquiries: This email address is being protected from spambots. You need JavaScript enabled to view it.
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About Us

CBS was set up by the Department of Atomic Energy and the University of Mumbai in 2007. CBS offers a 5 year integrated MSc program in Basic Sciences, with undergraduate teaching embedded in a postgraduate and research environment, for students who have completed 10+2 schooling or its equivalent.