Warning: include(/home/cbsac/public_html/pdf/exam_timetable/end-semester/dir.php): failed to open stream: No such file or directory in /home/cbsac/public_html/index.php on line 8

Warning: include(): Failed opening '/home/cbsac/public_html/pdf/exam_timetable/end-semester/dir.php' for inclusion (include_path='.:/usr/lib/php:/usr/local/lib/php') in /home/cbsac/public_html/index.php on line 8

Warning: session_start(): Cannot send session cookie - headers already sent by (output started at /home/cbsac/public_html/index.php:8) in /home/cbsac/public_html/libraries/joomla/session/session.php on line 658

Warning: session_start(): Cannot send session cache limiter - headers already sent (output started at /home/cbsac/public_html/index.php:8) in /home/cbsac/public_html/libraries/joomla/session/session.php on line 658
Manu Lopus
Manu Lopus
Reader 'F'
Manu Lopus | cbs.ac.in

Education:

  • Ph.D.: Indian Institute of Technology Bombay (2007)
  • M.Sc. St. Berchmans’ College, Mahatma Gandhi University, Kerala (2000)
  • B.Sc.: St. Berchmans’ College, Mahatma Gandhi University, Kerala (1998)

Positions:

  • Faculty, UM-DAE Centre for Excellence in Basic Sciences, Mumbai (2013 –)
  • Associate Specialist, University Of California, Santa Barbara (2011 – 2013)
  • Post-doctoral Fellow, University of California, Santa Barbara (2007 – 2011

Research:

  • Regulation of microtubule dynamics in cells
  • Tubulin isotype-mediated drug resistance
  • Chemotherapy-induced peripheral neuropathy
  • Roles of microtubule dynamics in cancer metastasis

Read More...

Peer-reviewed Publications:

  • Pradhan S, Mahaddalkar T, Choudhary S, Manchukonda N, Nagireddy PR, Kantevari S, and Lopus M* (2017) Elucidation of the tubulin-targeted mechanism of action of 9-(3-pyridyl) noscapine. Curr Top Med Chem (accepted)
  • Mahaddalkar T, and Lopus M* (2017) From Natural Products to Designer Drugs: Development and Molecular Mechanisms Action of Novel Anti-Microtubule Breast Cancer Therapeutics. Curr Top Med Chem (accepted)
  • Cheriyamundath S, Mahaddalkar T, Kantevari S, and Lopus M* (2016) Induction of acetylation and bundling of cellular microtubules by 9-(4-vinylphenyl) noscapine elicits S-phase arrest in MDA-MB-231 cells. Biomed Pharmacother (In Press)
  • Pradhan M, Suri C, Choudhary C, Naik PK, and Lopus M* (2016) Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol. J Biomol Struct Dyn (In Press)
  • Mahaddalkar T, Naik PK, Choudhary S, Manchukonda N, Kantevari S, Sanith C, and Lopus M* (2016) Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, by biochemical analyses and molecular dynamic simulations. J Biomol Struct Dyn (In Press)
  • Mahaddalkar T, Manchukonda N, Choudhary S, Cheriyamundath S, Mohanpuria N, Kantevari S, and Lopus M* (2016) Subtle alterations in microtubule assembly dynamics by Br-TMB-noscapine strongly suppress triple-negative breast cancer cell viability without mitotic arrest. ChemistrySelect, 1, 4313–4319
  • Maninder M, Singh D, Mahaddalkar T, Lopus M, et al. (2016) Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents. Bioorg Med Chem Lett, 26, 3855-3861
  • Lopus M, Smiyun G, Miller HP, Oroudjev E, Wilson L, and Jordan MA (2015). Mechanism of action of ixabepilone and its interactions with the βIII- tubulin isotype. Cancer Chemother Pharmacol (accepted). DOI: 10.1007/s00280-015-2863-z
  • Wilson L, Lopus M, Miller H, Azarenko O, Riffle S, Smith J, Jordan MA (2015) The effects of eribulin on microtubule binding and dynamic instability are strengthened in the absence of the βIII tubulin isotype. Biochemistry (accepted). DOI: 10.1021/acs.biochem.5b00745
  • Mahaddalkar T, Suri C, Naik PK, and Lopus M* (2015) Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent. Eur J Pharmacol (in press). doi:10.1016/j.ejphar.2015.04.014.
  • Mishra RC, Gundala SR, Karna P, Lopus M, Gupta KK, Nagaraju M, Hamelberg D, Tandon V, Panda D, Reid MD, and Aneja R (2015) Synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agents. Bioorg Med Chem Lett. (in press). doi. 10.1016/j.bmcl.2015.03.076.
  • Santoshi S, Manchukonda NK, Suri C, Das SK, Hota SK, Joseph S, Lopus M, Kantevari S, and Naik PK (2014) Rational design of biphenyl pharmacophore substituted noscapine derivatives as potent tubulin binding anticancer compounds. J Comput Aided Mol Des, 29, 249-70.
  • Lopus M* and Naik PK (2014) Taking aim at a dynamic target: Noscapinoids as microtubule-targeted cancer therapeutics. Pharmacol Rep, 67, 56-62.
  • Risinger AL, Riffle SM, Lopus M, Jordan MA, Wilson L, Mooberry, SL (2014) The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation. Mol Cancer  13 (1): 41
  • Manchukonda NK, Naik PK, Santoshi S, Lopus M, Joseph S, Sridhar B, and Kantevari  S (2013) Rational Design, Synthesis, and Biological Evaluation of Third Generation α-Noscapine Analogues as Potent Tubulin Binding Anti-cancer Agents. PLoS One, 8(10):e77970
  • Lopus M (2013) Mechanism of mitotic arrest induced by dolastatin 15 involves loss of tension across kinetochore pairs. Mol Cell Biochem, 382, 93-102
  • Lopus M, Manatschal C, Martinez R, Bjelic S, Steinmetz MO, Miller HP, and Wilson L (2012) Cooperative stabilization of microtubule dynamics by EB1 and CLIP-170 involves displacement of stably-bound Pi at microtubule ends. Biochemistry, 51, 3021-30
  • Pannu V, Rida PCG, Ogden A, Cheng A, Clewley R, Cheng A, Lopus M, Mishra RC, Zhou J, and Aneja R (2012) Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: A novel chemotherapeutic approach. Cell Death Dis, 3:e346
  • Naik PK, Lopus M, Aneja R, Vangapandu SN, and Joshi HC (2012) In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin). J Comput Aided Mol Des, 26, 233-47
  • Hinow P, Rasania V, Lopus M, Jordan MA, and Tuszynski J (2011) Modeling the effects of drug binding on dynamic instability of microtubules. Phys Biol, 8, 056004
  • Lopus M (2011) Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett, 307, 113-8 (Journal cover article)
  • Mishra RC, Karna P, Gundala SR, Stanton RA, Robinson M, Pannu V, Gupta KK, Lopus M, Henary M, Wilson L, and Aneja R (2011) Synthesis and biological evaluation of benzofuranone ring substituted analogs of noscapine. Biochem Pharmacol, 82, 110-21
  • Davé RH, Saengsawang W, Lopus M, Davé S, Sharma A, Wilson L, and Rasenick MM (2011) A molecular and structural mechanism for G-protein mediated microtubule destabilization. J Biol Chem, 286, 4319-28
  • Lopus M, Oroudjev E, Wilson L, Wilhelm S, Widdison W, Chari R, and Jordan, MA (2010) Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther, 9, 2689-99
  • Oroudjev E, Lopus M, Wilson L, Audette C, Provenzano C, Erickson H, Kovtun Y, Chari R, and Jordan MA (2010) Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability. Mol Cancer Ther, 9, 2700-13 (Journal cover image)
  • Yenjerla M, Lopus M, and Wilson L (2010) Analysis of dynamic instability of steady state microtubules in vitro by video-enhanced differential interference contrast microscopy. Method Cell Biol, 95, 185-206
  • Yenjerla M, LaPointe NE, Lopus M, Cox C, Jordan MA, Feinstein SC, and Wilson L (2009) The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules. J Alzheimer’s Dis, 19, 1377-86
  • Kotha S, Kashinath D, Lopus M, and Panda, D (2009) Synthesis of nano-sized C3-symmetric 2,4,6-triphenyl-1,3,5-s-triazene and 1,3,5-triphenyl benzene derivatives via the trimerization followed by Suzuki-Miyaura crosscoupling or O-alkylation reaction and their biological evaluation. Indian J Chem B: Org Chem Incl Med Chem, 12, 1766-70
  • Lopus M, Yenjerla M, and Wilson L (2009) Microtubule dynamics. In Wiley Encyclopedia of Chemical Biology, Begley TP, Ed. Wiley, NJ. 3, 153-60
  • Lopus M and Panda D (2006) The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding: a possible mechanism for its antiproliferative activity. FEBS J, 273, 2139-50
  • Aneja R, Lopus M, Zhou J, Vangapandu SN, Ghaleb A, Yao J, Nettles JH, Zhou B, Gupta M, Panda D, Chandra R, and Joshi HC (2006) Rational design of a microtubule targeting anti-breast cancer drug, EM015. Cancer Res, 66, 3782-91
  • Aneja R, Vangapandu SN, Lopus M, Panda D, and Joshi HC (2006) Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma. Mol Pharmacol, 69, 1801-09
  • Aneja R, Vangapandu SN, Lopus M, Viswesarappa VG, Verma A, Chandra R, Panda D, and Joshi HC (2006) Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death. Biochem Pharmacol, 72, 415-26

Address

UM-DAE Centre for Excellence in Basic Sciences
Health Centre, University of Mumbai,
Vidyanagari Campus, Kalina, Santacruz (East), Mumbai 400098, India.
Phone: 91-22-26524983
Fax: 91-22-26524982
General Enquiries: This email address is being protected from spambots. You need JavaScript enabled to view it.
Website Related: This email address is being protected from spambots. You need JavaScript enabled to view it.

About Us

CBS was set up by the Department of Atomic Energy and the University of Mumbai in 2007. CBS offers a 5 year integrated MSc program in Basic Sciences, with undergraduate teaching embedded in a postgraduate and research environment, for students who have completed 10+2 schooling or its equivalent.