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Jacinta S. D'Souza
Jacinta S. D’Souza
Associate Professor
Jacinta D'souza

Educational Qualifications:

  • M.Sc in Molecular Biology from TIFR
  • PhD in Molecular Biology from TIFR
  • Ex-Scientific Officer (until Jan’09) from TIFR

Positions held, including current

  • Scientific Asstt. – TIFR (1985 – 1998)
  • Scientific Officer – TIFR (1998 – 2009)
  • Reader 'F' (2010-2015)
  • Adjunct Professor, Manipal University (August 2015- )
  • Associate Professor (January 2016- )

Research areas

  • Protein-Protein Interactions, Chlamydomonas stress physiology, Flagellar Biology

List of selected publications

  • Rao V. G., Sarafdar Ruhi, Twinkle Chaudhary, Priyanka Sivadas, Pinfen Yang and D’Souza J. S. (2016) An AKAP240 binding flagellar-associated protein from Chlamydomonas reinhardtii. BMC Cell Biology 17: 24-33
  • J. A. Dharmadhikari, A. K. Dharmadhikari, K. C. Kasuba, H. Bharambe, J. S. D’Souza, K. D. Rathod and D. Mathur, (2016) Optical control of filamentation induced damage to DNA by intense, ultrashort, near-infrared laser pulses. Scientific Reports 6:27515 | DOI: 10.1038/srep27515.
  • Dolly K. Khona, Seema Shirolikar, Deodhar, Erik Hom, D’Souza J. S., (2016) NaCl-induced palmelloidy in the green chlorophyte, Chlamydomonas reinhardtii. Algal Research, 16: 434-448.
  • Sirisha V. L., Mahuya Sinha, Kanak Gawade and Jacinta S. D’Souza, (2016) KCl Induces PCD through a Mitochondrion-mediated Caspase-independent Pathway in Chlamydomonas reinhardtii. Phycologia, 55: 378-392
  • Aditya K. Dharmadhikari, Harish Bharambe, Jayashree A. Dharmadhikari, Jacinta S. D’Souza and Deepak Mathur, (2014) Ultrafast laser induces both single stranded and double stranded breaks in plasmid DNA. Physics Review Letters 112: 138105.
  • K. C. Kasuba, S. L. Vavilala, J. S. D'Souza (2015) Apoptosis-like cell death in unicellular photosynthetic organisms—A review. Algal Research 12: 126-133
  • S. L. Vavilala, K. K. Gawde, M. Sinha, J. S. D’Souza, (2015) Programmed cell death is induced by hydrogen peroxide but not by excessive ionic stress of sodium chloride in the unicellular green alga Chlamydomonas reinhardtii. European Journal of Phycology 50: 422-438.
  • Mustafa J. Motiwalla, Marilyn P. Sequeira and Jacinta S. D’Souza, (2014) Two Calcium-Dependent Protein Kinases from Chlamydomonas reinhardtii are transcriptionally regulated by nutrient starvation. Plant Signaling and Behaviour 9: e27969 (10.4161/psb.27969).
  • Sirisha V. L., Mahuya Sinha and Jacinta S. D’Souza, (2014) Menadione-induced caspase-dependent programmed cell death in the green alga Chlamydomonas reinhardtii. Journal of Phycology 50: 587–601.
  • Aditya K. Dharmadhikari, Harish Bharambe, Jayashree A. Dharmadhikari, Jacinta S. D’Souza and Deepak Mathur, (2014) Ultrafast laser induces both single stranded and double stranded breaks in plasmid DNA. Physics Review Letters 112: 138105.
  • Elvis A. F. Martis, Rakesh C. Chandarana, Mushtaque S. Shaikh, Premlata K. Ambre, Santosh R. Nandan, Jacinta S. D’Souza, Krishna R. Iyer, Evans C. Coutinho and Raghuvir R. S. Pissurlenkar, (2014) Quantifying Ligand-Receptor Interactions for Gorge Spanning Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s disease. Journal of Biomolecular Structure and Dynamics 33: 1107-1125.
  • Dolly Khona*, Venkatramanan Rao*, Mustafa J. Motiwalla, Sreekrishna Varma P. C., Anisha Kashyap, Koel Chaudhary, Seema Shirolikar, Lalit Borde, Jayashree A. Dharmadhikari, Aditya K. Dharmadhikari, Siuli Mukhopadhyaya, D. Mathur and Jacinta S. D'Souza. (2013) Anomalies in the motion dynamics of long-flagella mutants of Chlamydomonas reinhardtii. (*Equal contribution) J of Biological Physics 39: 1-14.
  • Dolly K. Khona, Dongre Shounak and Jacinta S. D'Souza, (2013) BolA-like protein from the green chlorophyte Chlamydomonas reinhardtii is an oligomer and induces biofilm formation in E. coli. FEMS Letters 339: 39–47.
  • Rakesh C. Chandarana, Vikrant , Ashok K. Varma, Anil Saran, Evans Coutinho, Jacinta S. D'Souza, (2013) Over-expression, purification and isotopic labeling of a tag-less human glucose-dependent insulinotropic polypeptide (hGIP) 3Biotech 4: 501-506.
  • Motiwalla, M. J., Priyanka P. Punyarthi, Mansi K. Mehta, D'Souza, J. S. and Kelkar-Mane, V. (2013) Isolation and characterization of poly-capro-lactone degrading strain of Bacillus pumilus from the rhizosphere of the mangrove Sessuvium portulacastrum. J of Environmental Biotechnology, 34: 43-49.
  • J. S. D’Souza, J. A. Dharmadhikari, A. K. Dharmadhikari, B. J. Rao, and D. Mathur, (2011) Effect of intense, ultrashort laser pulses on DNA plasmids in their native state: Strand breakages induced by in situ electrons and radicals. Physics Review Letters 106: 118101. Comment in Nature, India; Laser tells tale of DNA injury, doi:10.1038/nindia.2011.50; Published online 18 April 2011 (http://www.nature.com/nindia/2011/110418/full/nindia.2011.50.html)
  • Jacinta S. D'Souza, Mohanram Gudipati, Jayashree A. Dharmadhikari, Aditya K. Dharmadhikari, *Abhishek Kashyap, *Manaswini Aiyer, Usha Rao, Deepak Mathur and Basuthkar Jagadeeshwar Rao, (2009) Flagella-generated forces reveal gear-type motor in single cells of the green alga, Chlamydomonas reinhardtii. (2009) Biochem. Biophys. Res. Comm. 380: 266–270 (*Equal contribution).
  • Swati Moharikar, Jacinta D’Souza and B. J. Rao. (2007) A homolog of the defender against apoptotic death gene (DAD1) is down regulated prior to the onset of apoptosis-like cell death in UV-exposed Chlamydomonas reinhardtii cells. Journal of BioScience 32: 261-270.
  • JA Dharmadhikari, JS D'Souza, M Gudipati, AK Dharmadhikari, BJ Rao, Deepak Mathur, (2006) Sensitive, real-time monitoring of UV-induced stress in a single, live plant cell using an optical trap. Sensors and Actuators B: Chemical 115: 439-443.
  • Swati Moharikar, Jacinta D'Souza, Atul B. Kulkarni, and B. J. Rao, (2006) UV-C induced apoptotic-like cell death process in the unicellular chlorophyte Chlamydomonas reinhardtii. Journal of Phycology 42: 423-433.
  • M Gudipati, J D'Souza, J Dharmadhikari, A Dharmadhikari, B Rao, D Mathur, (2005) Optically-controllable, micron-sized motor based on live cells. Optics Express 13: 1555-1560.
  • Motiwalla, M. J., Priyanka P. Punyarthi, Mansi K. Mehta, D'Souza, J. S. and Kelkar-Mane, V. (2013) Isolation and characterization of poly-capro-lactone degrading strain of Bacillus pumilus from the rhizosphere of the mangrove Sessuvium portulacastrum. J Environmental Microbiology.
  • Suruchi Jamkhedkar, Jyotsna Dongerdive, Kavita Jain, Siby Abraham and Jacinta S. D'Souza, (2013) Arrangement of flagella on cells: two flagella clusters emerge. Advances in Bioscience and Biotechnology, 4: 93-102
  • Rakesh C. Chandarana, Vikrant , Ashok K. Varma, Anil Saran, Evans Coutinho, Jacinta S. D'Souza, (2013) Over-expression, purification and isotopic labeling of a tag-less human glucose-dependent insulinotropic polypeptide (hGIP) 3 Biotech DOI 10.1007/s13205-013-0181-x
  • Mustafa J. Motiwalla, Marilyn P. Sequeira and Jacinta S. D'Souza, (2014) Two Calcium-Dependent Protein Kinases from Chlamydomonas reinhardtii are transcriptionally regulated by nutrient starvation, In Press, Plant Signaling and Behavior

Address

UM-DAE Centre for Excellence in Basic Sciences
Health Centre, University of Mumbai,
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About Us

CBS was set up by the Department of Atomic Energy and the University of Mumbai in 2007. CBS offers a 5 year integrated MSc program in Basic Sciences, with undergraduate teaching embedded in a postgraduate and research environment, for students who have completed 10+2 schooling or its equivalent.