Director: Ramakrishna V. Hosur
Born, 1953; B. Sc from Karnatak University; M. Sc (Chemistry) from IIT-Bombay; Ph. D from TIFR (Mumbai university); Post-doc at ETH Zurich (Prof. Kurt Wuthrich, NL); Employed at TIFR since 1978, currently, Senior Professor.
Pioneered research in biomolecular NMR, molecular biophysics, biophysical chemistry. Published over 150 research articles in journals; Written and Edited books.; Taught courses at TIFR, IIT-Bombay, IIT-Roorkee on NMR, mathematics, biophysics; Guided 20 Ph. D students.
Discovered new structural motifs in quadruplex DNA structures: A-tetrad, T-tetrad, C-tetrad. • Developed new multidimensional NMR pulse sequences. • Elucidated the folding hierarchy in HIV-1 protease. • Developed ‘scaling techniques’ for sensitivity and resolution enhancement. • Suggested a pH switch mechanism for cargo trafficking by DLC8 protein inside living cells. • Elucidated the native state energy landscape, and structural and dynamic characteristics of SUMO-1 protein along the equilibrium folding pathways; demonstrated that the native contacts do not progress monotonously. • Elucidated by NMR the self-association pathway of GED domain of dynamin into a large >5 MDa assembly.
Convener, National Facility for high field NMR; Member of sectional committees of INSA, Indian Academy of Sciences AND NATIONAL Academy of Sciences; DST, CSIR and DBT expert committees; Chair, IUPAB national committee of INSA (2008-2011); council member, INSA (2008-2010); RC member, IICB, Kolkata; President, Indian Biophysical Society; President, new biology section of Indian Science Congress, 2005; President, National Magnetic Resonance Society (NMRS) (2009-11); Council Member, Centre for Biomedical Research, Lucknow; Member, Council of International Conference on Magnetic Resonance in Biological Systems (2004-2014)
Indian Academy of Sciences (1994); National Academy of Sciences (1997); Indian National Science Academy (1995); The World Academy of Sciences (2008)